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Stable reprogramminStable reprogramming of brain transcription profiles by the early social environm

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#1 - Posted: 20 Lut 2013 10:02 
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Stable reprogramming of brain transcription profiles by the early social environment in a cooperatively breeding fish.


Abstract

Adult social behaviour can be persistently modified by early-life social experience. In rodents, such effects are induced by tactile maternal stimulation resulting in neuroendocrine modifications of the hypothalamic–pituitary–adrenal axis involved in stress responsiveness. Whether similar long-term alterations can occur in the hypothalamic–pituitary–interrenal (HPI) axis of poikilothermic vertebrates is unknown. We compared the expression of four genes of the HPI axis in adults of the cooperatively breeding cichlid Neolamprologus pulcher, which had been exposed to two early-life social treatments 1.5 years prior to brain sampling. Fish reared with parents and siblings had less brain expression of corticotropin-releasing factor and of the functional homologue of the mammalian glucocorticoid receptor (GR1) than individuals reared with same-age siblings only. Expression of the mineralocorticoid receptors (MR) did not differ between treatments, but the MR/GR1 expression ratio was markedly higher in fish reared with parents and siblings. Thus, we show here that early social experience can alter the programming of the stress axis in poikilothermic vertebrates, suggesting that this mechanism is deeply conserved within vertebrates. Moreover, we show for the first time that reprogramming of the stress axis of a vertebrate can be induced without tactile stimulation by parents.




Streszczenie po polsku można przeczytać tutaj http://www.cichlidae.com/docs/news.php?lang=pl

To rewolucyjne odkrycie!

Marta

Literatura Forum Tropheus Tanganika / Literatura / Stable reprogramminStable reprogramming of brain transcription profiles by the early social environm Top

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